urothelial carcinoma
Conditions
Interventions
On the first day of 28days, cisplatin(CDDP) 70mg/m2 and gemcitabine(GEM) 1000mg/m2 are intravenously infused, with about 1L of drinking water and a total of about 2L of fluid replacement by the end of
Sponsors
Ministry of Education, Culture, Sports, Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Urothelial carcinoma 2)WBC>=3,000/x10^(-6)L,PLT>=10,000/x10^(-6)L,Hb>=10g/dL,Ccr>=60mL/min 3)sufficient understanding of drinking water instruction has been made 4)Cardiac function is retained 5)Performance Status 0-1 6)With no serious complications 7)Patient consent is obtained
Exclusion criteria
Exclusion criteria: 1)There is a sever kidney dysfunction(Ccr<60mL/min) 2)WBC<3,000/x10^(-6)L, PLT<10,000/x10^(-6)L 3)Evident in the chest X-ray, and has a interstitial pneumonitis or pulmonary fibrosis of clinical symptoms 4)Underwent radiation therapy to the chest 5)Merged with serious infections 6)Women suspected of being pregnant or pregnant 7)Patients with hypersensitivity to the drug to use and the drug including the platinum 8)Patients attending physician has determined ineligible in the practice of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in estimation glomerular filtration rate between before and after the course | — |
Countries
Japan
Contacts
Public ContactToshifumi Hashimoto
Aichi Medical University Hospital Administration Division
Outcome results
None listed