Healthy adults
Conditions
Interventions
1. Single-dose study Test materials: 50 mg of plant-derived ingredients containing tablets Duration: 1 day Administration: After two hours at intake 8 tablets of the test food, measure swelling *D
Sponsors
SAPPORO HOLDINGS LTD.
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Healthy adults Japanese women 2. Those who received a full explanation of the procedures in the study, and informed consent was documented and signed by all of the participants
Exclusion criteria
Exclusion criteria: 1. To diagnose kidney function works abnormity (urine proteins, creatinine etc. as biomarker) by urinalysis 2. Diastolic pressure is more than 135 mmHg 3. Those who are allergic to citrus fruits 4. Those who are pregnant, breast-feeding, or are expected to become pregnant during the test period 5. Those who had and plan to have surgery and/or hospitalization within 2 months before and after the study period of Nov. 2016 to May 2017 6. Others consider as inappropriate for this test by the physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Subjective symptoms for swelling: questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Leg swelling Water tank volume immersion and calf circumference 2. Facial swelling High resolution analyzed image, moisture, oiliness, skin tone, pigmentation (the number of pigmentations and total area of pigmentations), pores, wrinkle (the number of wrinkles and total length and areas), texture 3. Subjective symptoms related to swelling of health: questionnaire | — |
Countries
Japan
Contacts
Public ContactKazuhiko YOSHIKAWA
SAPPORO HOLDINGS LTD. Group Research and Development Division
Outcome results
None listed