Effect of basic fibroblast growth factor (bFGF) in combination with natural bone mineral on periodontal regeneration

Effect of basic fibroblast growth factor (bFGF) in combination with natural bone mineral on periodontal regeneration - Effect of bFGF (FGF-2) and natural bone mineral (DBBM) on periodontal regeneration

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025257

Enrollment

Registered

2017-08-01

Start date

2016-12-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

Use of bFGF (FGF-2

REGROTH) 0.27 mL or 0.47 mL during periodontal surgery Use of bFGF (FGF-2

REGROTH) 0.27 mL or 0.47 mL plus natural bone mineral (Bio-Oss) during periodontal surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with periodontitis who have completed initial periodontal therapy and: 1. with probing depth >= 4 mm 2. with vertical bone defect >= 3 mm

Exclusion criteria

Exclusion criteria: Patients with uncontrolled systemic diseases, those with allergic reactions to bFGF or Bio-Oss,or other medications, those with (or had) oral malignant tumor, in pregnancy or nursing, those receiving anti-coagulant drugs or any other drugs that may influence the clinical results.

Design outcomes

Primary

Measure	Time frame
Gain in Clinical Attachment level (at 6 months after intervention)	—

Secondary

Measure	Time frame
Probing depth Bleeding on probing Tooth mobility Radiographic bone level Oral health-related QoL score	—

Countries

Japan

Contacts

Public ContactAtsushi Saito

Tokyo Dental College Department of Periodontology

atsaito@tdc.ac.jp03-6380-9172

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026