Major psychiatric disorder (Schizophrenia, Bipolar disorder, and Depression)
Conditions
Interventions
Brain MRI/Parent diagnosed with major psychiatric disorder and healthy offspring pair
Brain MRI/Healthy parent-offspring pair
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ?Schizophrenia, bipolar disorder, and depression diagnosed based on DSM-5 and their healthy biological offsprings ?Healthy parent and their biological offspring pairs ?Healthy controls scored more than 24 points in MMSE or 70 in JART ?Reliable informed consent could be obtained from the patient and or his her relatives
Exclusion criteria
Exclusion criteria: ?Participants were required to have had no lifetime history of any psychiatric disorders, or drug or alcohol misuse, as well as no neurological disorder ?None of the participants reported unstable medical condition and history of significant head trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The brain regions where specific parent-offspring pairs (e,g, depressed mother and high-risk daughter dyads) consistently show greater associations compared to other parent and offspring dyads (e.g, depressed father and high-risk son dyads). | — |
Countries
Japan
Contacts
Public ContactBun Yamagata
Keio University School of Medicine Department of Neuropsychiatry
Outcome results
None listed