A randomized controlled trial of cognitive behavior therapy as an adjunct to usualcare for panic disorder refractory to medical treatment

A randomized controlled trial of cognitive behavior therapy as an adjunct to usualcare for panic disorder refractory to medical treatment - RCT about the effectiveness of the CBT for medical treatment-resistant panic disorder patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025220

Enrollment

Registered

2016-12-11

Start date

2016-12-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

panic disorder

Interventions

cognitive behavioral therapy(16 weeks) usual care only(16 weeks)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Primary diagnosis of Panic Disorder refractory to medicine(Taking antidepressant or anti-anxiety drugs treatment and had done so for at least 8 weeks at an adequate dose while remaining at least moderately ill(PDSS >=8)).

Exclusion criteria

Exclusion criteria: psychosis, major depression, bipolar, active suicidality, organic brain disorder, substance abuse or dependence, antisocial personality disorder, other severe mental / physical condition

Design outcomes

Primary

Measure	Time frame
Panic Disorder Severity Scale(PDSS)(assessor-rated)	—

Secondary

Measure	Time frame
PAS(Panic and Agoraphobia Scale) PHQ-9(Patient Health Questionnare-9) GHQ-7(Generalized anxiety disorder-7) EQ-5D-5L(EuroQol5-Dimension-5Levels) MDS(Mental Defeat Scale) CFS(Cognitive Flexibility Scale)	—

Countries

Japan

Contacts

Public ContactYoichi Seki

Chiba University Hospital Cognitive Behavioral Therapy Center

yoichi-seki@chiba-u.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026