Effects of early enteral nutrition in acute stroke patients: an open-label randomized study

Effects of early enteral nutrition in acute stroke patients: an open-label randomized study - Early enteral nutrition in acute stroke patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025075

Enrollment

Registered

2016-12-01

Start date

2017-01-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Early enteral nutrition via a nasogastric tube with an oligomeric formula containing hydrolyzed whey protein within 24 hours after admission. Enteral nutrition with a polymeric formula via a nasogastr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Stroke patients within 24 hours from onset. 2. An inadequate or unsafe oral intake.

Exclusion criteria

Exclusion criteria: 1. Use of antibiotics within 3 months 2. Infection at admission 3. Malignant tumor 4. Autoimmune diseases 5. Postoperative state due to gastrointestinal disorders 6. Liver or renal failure 7. Poorly controlled diabetes

Design outcomes

Primary

Measure	Time frame
Changes of the serum levels of inflammatory markers (interleukin-6, high sensitivity CRP) , LPS binding protein and an intestinal permeability marker (zonulin) from the first to seventh and fourteenth feeding days.	—

Secondary

Measure	Time frame
Frequency of infection National institute of health stroke scale Modified Rankin Scale	—

Countries

Japan

Contacts

Public ContactKazuo Yamashiro

Juntendo University School of Medicine Department of Neurology

kazuo-y@juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026