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Quantitative evaluation of T1 shortening in myocardium and left ventricle cavity by three different macrocyclic gadolinium based contrast agents

Quantitative evaluation of T1 shortening in myocardium and left ventricle cavity by three different macrocyclic gadolinium based contrast agents - Quantitative evaluation of T1 shortening in heart by three different gadolinium based contrast agents

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000025067
Enrollment
40
Registered
2016-12-01
Start date
2015-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart disease

Interventions

None listed

Sponsors

Gunma University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who underwent cardiac magnetic resonance imaging with T1 mapping before and after administration of gaddolinium contrast agents

Exclusion criteria

Exclusion criteria: - Examinations without T1 mapping sequence - Diffuse myocardial lesion

Design outcomes

Primary

MeasureTime frame
T1 mapping was conducted using modified look-locker inversion recovery (MOLLI) sequences to measure the T1 relaxation time values of the myocardium and LV (1). Regions of Interest were drawn on the short axis images of areas of the myocardium without lesion involvement, at the LV septal/inferior walls, and in the LV cavity. An inversion scout sequence was also acquired seven min after mGBCA administration. Null points were defined as the inversion times (TI) that showed the lowest intensities of the myocardium and LV in each patient. The biological parameters of ejection fraction, estimated glomerular filtration rate, hematocrit, and heart rate were also compared across the three groups.

Countries

Japan

Contacts

Public ContactNakajima Takahito

Gunma University Hospital Diagnostic Radiology and Nuclear Medicine

sojin@gunma-u.ac.jp027-220-8401

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026