A randomized open-label positive-controlled crossover study of clinical efficacy of different type of inhaler devices for asthmatics with eosinophilic rhinosinusitis

A randomized open-label positive-controlled crossover study of clinical efficacy of different type of inhaler devices for asthmatics with eosinophilic rhinosinusitis - Clinical efficacy of different type of inhaler devices for asthmatics with ECRS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025040

Enrollment

Registered

2017-01-01

Start date

2017-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma with eosinophilic chronic rhinosinusitis

Interventions

Adair Discus 500 microgram one inhalation twice daily for 8 weeks, followed by Relvar Ellipta 200 microgram one inhalation once daily for 8 weeks Relvar Ellipta 200 microgram one inhalation once dail

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. patients with good asthma control under more than 8 weeks treatment with Adair Aerosol 250 microgram 2 inhalation twice daily though the nose 2. non-smoker

Exclusion criteria

Exclusion criteria: 1. exacerbation within 4 weeks (eg. infection and asthma attack) 2. concomitant disease currently treated (eg. heart diseases, hematologic disorders, respiratory diseases) 3. pregnant patients 4. possibility of lack of examination security.

Design outcomes

Primary

Measure	Time frame
Levels of fractionated exhaled nitrogen oxide 8 weeks after starting each trial drug administration	—

Secondary

Measure	Time frame
Lung function, nasal polyp score and sinus CT score 8 weeks after starting each trial drug administration	—

Countries

Japan

Contacts

Public ContactYoshiki Kobayashi

Kansai Medical University Department of Otolaryngology, Neck and head surgery

kobayosh@hirakata.kmu.ac.jp072-804-0101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026