The study for the hepatoprotective effect of steroid administration before hepatectomy in major hepatectomy with extrahepatic bile duct resection.

The study for the hepatoprotective effect of steroid administration before hepatectomy in major hepatectomy with extrahepatic bile duct resection. - The study for the hepatoprotective effect of steroid administration before hepatectomy.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025039

Enrollment

Registered

2016-12-17

Start date

2017-01-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients who are scheduled to undergo major hepatectomy with extrahepatic bile duct resection.

Interventions

In the steroid group, hydrocortisone will be administered intravenously before hepatectomy (500mg), on postoperative day 1 (300mg), on postoperative day 2 (200mg), and on postoperative day 3 (100mg).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who are scheduled to undergo major hepatectomy with extrahepatic bile duct resection (for any disease). 2. Patients who agree to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Patients who reject to participate in the study. 2. Patients who are not eligible to participate in the study (by decision of the investigators).

Design outcomes

Primary

Measure	Time frame
The incidence rate of posthepatectomy liver failure.	—

Secondary

Measure	Time frame
Postoperative liver injury. Postoperative complications other than the liver failure. Postoperative inhospital day.	—

Countries

Japan

Contacts

Public ContactYukihiro Yokoyama

Nagoya University Hospital Gastrointestinal Surgery 1

yyoko@med.nagoya-u.ac.jp0527442218

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026