Cognitive effects of adjunctive perampanel in patients with refractory epilepsy: an open-label, comparative study

Cognitive effects of adjunctive perampanel in patients with refractory epilepsy: an open-label, comparative study - Cognitive effects of perampanel

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025026

Enrollment

Registered

2016-12-01

Start date

2017-01-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Interventions

Patients are treated with perampanel for 48 weeks. Patients are treated with other antiepileptic drugs for 48 weeks.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients had at least one partial seizure during the previous 3 months, despite a stable regimen of 1 or more antiepileptic drugs.

Exclusion criteria

Exclusion criteria: 1. Pregnant or breast feeding 2. Simple partial seizure without motor symptoms 3. Primary generalized epilepsy 4. Psychiatric disorders 5. Unstable coronary heart disease 6. Drug and alcohol abuse 7. Surgical indication 8. Difficult to make decisions about participation due to severe cognitive impairment

Design outcomes

Primary

Measure	Time frame
Changes of cognitive assessment scores from baseline after 48 weeks	—

Secondary

Measure	Time frame
Seizure frequency Adverse events	—

Countries

Japan

Contacts

Public ContactKazuo Yamashiro

Juntendo University School of Medicine Department of Neurology

kazuo-y@juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026