Effect of Bifidobacteria intake on oral environment

Effect of Bifidobacteria intake on oral environment - Effect of Bifidobacteria intake on oral environment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000025000

Enrollment

Registered

2017-01-15

Start date

2017-01-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis

Interventions

Bifidobacterium containing yogurt intake once a day for 8 weeks Bifidobacterium non-containing yogurt intake once a day for 8 weeks Sham control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Chronic Periodontitis Maintenance phase Probing pocket depths 5mm<=, =>7mm

Exclusion criteria

Exclusion criteria: Patients with serious disease Allergy in food (especially dairy product) Smoker Lactating period Pregnant Antibiotics intake during 3 months Antiplatelet agent intake Yogurt, fermented milk drink and intestinal drug intake more than three times a week during 3 months Participated in other clinical trials during one month Drugs, supplements and foods which affect the result of the trial

Design outcomes

Primary

Measure	Time frame
Bacterial flora(Saliva, subgingival plaque) Porphyromonas gingivalis, Treponema denticola, Tannerella forsythensis (Observation period; 4 months)	—

Secondary

Measure	Time frame
Ig A (Saliva) Probing pocket depth Bleeding on probing Gingival index	—

Countries

Japan

Contacts

Public ContactTatsuya Akizuki

Tokyo Medical and Dental University Department of Periodontology

akizuki.peri@tmd.ac.jp03-5803-5488

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026