Aquagenic wrinkling of the palms, palmoplantar keratoderma, palmoplantar hyperhidrosis, healthy subjects
Conditions
Interventions
Loxoprofen sodium hydrate tape, once a day, pasted on the fingers for 3 to 6 months, 1% diclofenac sodium gel and lotion, topical application to the palm for 3 to 6 months twice a day, 20% or 30% alum
Sponsors
Keio university school of medicine, Department of dermatology
Tohoku University Graduate School of Biomedical Engineering
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who have skin maceration by exposure to water with Aquagenic wrinkling of the palms, palmoplantar keratoderma and palmoplantar hyperhidrosis, and healthy subjects
Exclusion criteria
Exclusion criteria: 1) Patients who can not inform disease name. 2) Patients with aspirin asthma and a previous medical history of it. 3) Patients with a history of hypersensitivity to diclofenac sodium, sodium loxoprofen hydrate. 4) Case of pregnancy or expected pregnancy (hope / plan) 5) Cases with age less than 6 at the time of consent acquisition 6) Patients who are judged inappropriate by doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate degree of maceration before and after water immersion test on each visit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Observe the morphology of the palmar skin with an ultrasonic microscope (at the start and the end of the test). Create and compare replica of finger skin print before and after water immersion test (as much as possible on each visit). Self assessment of skin symptoms (per visit). | — |
Countries
Japan
Contacts
Public ContactAkiharu Kubo
Keio university school of medicine Department of dermatology
Outcome results
None listed