exosome-focused translational research for afatinib

Conditions

Lung Cancer

Morikawa K, Takata S, Tanaka H, Itani H, Ishihara M, Horiuchi K, Kato Y, Ikemura S, Nakagawa H, Nakahara Y, Seki Y, Bessho A, Takahashi N, Hayashi K, Endoh T, Takeyama K, Maekura T, Takigawa N, Kawase A, Endoh M, Nemoto K, Kishi K, Soejima K, Okuma Y, Yoshimura K, Saigusa D, Kanai Y, Ueda K, Togashi A, Matsutani N, Seki N.

2026-02-11

10.1038/s41598-026-38944-3

Prospective exosome-focused translational research for afatinib (EXTRA) study of patients with nonsmall cell lung cancer harboring <i>EGFR</i> mutation: an observational clinical study

Saori Takata, Kei Morikawa, Hisashi Tanaka, Hidetoshi Itani, Masashi Ishihara et al. (31 authors)

Therapeutic Advances in Medical Oncology2023-01-016 citations

10.1177/17588359231177021

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: non small cell lung cancer diagnosed adenocarcinoma having Ex19 mutation, Ex.21 mutation, uncommon mutation using afatinib as first line treatment ECOG PS 0,1 healthy patient It is expected to survive for at least 3 months. writing consent is obtained

Exclusion criteria

Exclusion criteria: Illegal disorders such as idiopathic pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, active radiation pneumonitis, drug pneumonia, etc. are complicated synchronous or allochronic malignancies having the history of preoperative anticancer treatments

Design outcomes

Primary

Measure	Time frame
Identification of pharmacological markers and resistance factors of afatinib using exosome-derived molecules	—

Secondary

Measure	Time frame
Relationship between various factors and response rate, disease control ratio, progression-free survival time, overall survival time Consideration of compatibility of results between serum specimen and serum exosome specimen	—

Countries

Japan

Contacts

Public ContactNoriyuki Matsutani

Teikyo University School of Medicine Surgery

matsutan@med.teikyo-u.ac.jp03-3964-1231

Outcome results