Evaluation of the relation between carnitine deficiency and fatigue in patients with head and neck carcinoma under induction chemotherapy

Evaluation of the relation between carnitine deficiency and fatigue in patients with head and neck carcinoma under induction chemotherapy - Evaluation of the relation between carnitine deficiency and fatigue in patients with head and neck carcinoma under induction chemotherapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000024910

Enrollment

Registered

2019-12-31

Start date

2016-10-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck carcinoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient with untreated head and neck carcinoma and receiving individualized treatment regimens of Docetaxel, Cisplatin and 5FU as developed. StageI, II, III and IVA ECOG PS 1 and 2

Exclusion criteria

Exclusion criteria: Patients with hypersensitivity to levocarnitine. Patients who takes levocarnitine within one month from the present. Pregnant female and nursing female. Patient that informed concent is not provided. Patient with sereous renal failure Patient with insulin dependent diabetes mellitus, diabetic ketoacidosis and metabolic acitosis

Design outcomes

Primary

Measure	Time frame
Serum carnitine levels include free body, acyl body and total before and after induction chemotherapy	—

Secondary

Measure	Time frame
Fatigue used VAS scale before and after induction chemotherapy. Body component include body weight, volume of skeletal muscle and fat, BMI, BCM and AC% used In Body. Volume of skeletal muscle and fat used computed tomography. Clinical biochemistry and hematology include AST, ALT, ALP, Alb, T-Bil, BUN, Cr, PLT, PT(s), TP, T-Cho, Ch-E, TG, FFA, Pr-Alb, CRP, blood glucose level,RBC, WBC, Hb.	—

Countries

Japan

Contacts

Public ContactHiroki Sato

Tokyo Medical University Department of Otorhinolaryngology, Head and Neck Surgery

satohiro1979@yahoo.co.jp03-3346-9275

Outcome results