Investigation of the transdermal absorption effect of clary sage essential oil on hot flashes of menopausal women

Investigation of the transdermal absorption effect of clary sage essential oil on hot flashes of menopausal women - Investigation of the transdermal absorption effect of clary sage essential oil on hot flashes of menopausal women

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000024894

Enrollment

Registered

2016-11-18

Start date

2015-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menopause(hot flashes)

Interventions

Intervention group (percutaneous absorption group) Apply 1 ml of clary sage essential oil diluted 2% in jojoba oil to the lower abdomen for 10 minutes. The essential oil is used at the front of the l

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Yokohama Port Side Female General Clinic Patient, Zushi Medicine Clinic Patient Yokohama City University staff, Yokohama City University affiliated hospital staff, Yokohama City University attached citizen general medical center staff

Exclusion criteria

Exclusion criteria: (1)HRT was enforced within 30 days before the start of the study. (Women 's medicine and supplements of Chinese herbal medicine and general medicine not containing estrogen preparation are acceptable.) (2)Allergy against essential oil used (3)There is skin disease (4)HRT and Surgical menopause treatment is in effect (5)Menopausal symptom interview sheet (Document IV) There are other diseases that fall under Q4 (2) - (16) (not limited to the presence or absence of treatment) (6)Participate in other exams within 30 days before the exam (7)In addition, patients judged unsuitable as subjects by doctor's judgment

Design outcomes

Primary

Measure	Time frame
Evaluate the following items 21 days after the start of intervention. Symptom change of hot flashes: Evaluation of change occurring in the number of times and degree of hot flash by hot flash memory. Estrogenic activity: For each test, about 20 ml of urine is collected on the first day and the last day of the test and E2, FSH, LH are chromatographed, and the difference in hormone levels occurring between the intervention group and the control group is evaluated. Physical symptom change of menopausal disorder: Relative evaluation in somatic symptom change of 14 items described in hot flash memory	—

Measure

Time frame

Evaluate the following items 21 days after the start of intervention. Symptom change of hot flashes: Evaluation of change occurring in the number of times and degree of hot flash by hot flash memory. Estrogenic activity: For each test, about 20 ml of urine is collected on the first day and the last day of the test and E2, FSH, LH are chromatographed, and the difference in hormone levels occurring between the intervention group and the control group is evaluated. Physical symptom change of menopausal disorder: Relative evaluation in somatic symptom change of 14 items described in hot flash memory

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Countries

Japan

Contacts

Public ContactTomoko Akase

Yokohama City University Department of Biological Science and Nursing, Graduate School of Medicine

akase@yokohama-cu.ac.jp045-787-2743

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026