The effect of proton pump inhibitor and potassium competitive acid blocker toward endothelial cells.

The effect of proton pump inhibitor and potassium competitive acid blocker toward endothelial cells. - The effect of PPI and P-CAB toward endothelial cells.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000024875

Enrollment

Registered

2017-01-01

Start date

2017-01-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy adults

Interventions

Taking PPI(8weeks) before PCAB(8weeks) per os.Between them, there is 2 weeks no medication time for wash out. Taking PCAB(8weeks) before PPI(8weeks) per os.Between them, there is 2 weeks no medication

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: AST>80 or ALT>80 Cr>1.5 No diseases No drug addiction No alcohol addiction Those with written consent

Exclusion criteria

Exclusion criteria: current smoker HbA1Cis over 6.5 BMIis over 30 Those who take other drugs. Those who have the history of hypertension, atherosclerosis. Those who are not allowed by research doctors.

Design outcomes

Primary

Measure	Time frame
We evaluate how PPI and PCAB effect to endothelial cells after 8week medication by measuring ADMA and FMD.	—

Countries

Japan

Contacts

Public ContactChiaki Kamiya

Hamamatsu University School of Medicine Department of Clinical Pharmacology and Therapuetics

ilka122@hama-med.ac.jp053-435-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026