Effects of dl-methylephedrine on cognitive functions in normal adults using fMRI: randomized, placebo-controlled, double-blind, comparative study

Effects of dl-methylephedrine on cognitive functions in normal adults using fMRI: randomized, placebo-controlled, double-blind, comparative study - Effects of dl-methylephedrine on cognitive functions in normal adults using fMRI: randomized, placebo-controlled, double-blind, comparative study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000024842

Enrollment

Registered

2016-11-15

Start date

2016-11-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

1 day, 1 time, dl-methylephedrine 60mg washout duration 1 week 1 day, 1 time, placebo 1 day, 1 time, placebo washout duration 1 week 1 day, 1 time, dl-methylephedrine 60mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects with no history of psychiatric disorders. Subjects with normal BMI (18.5-25) Subjects who have the ability to provide informed consent and adhere to the protocol.

Exclusion criteria

Exclusion criteria: Subjects with drug allergy. Subjects taking drugs within 2 weeks of the trial. Subjects with hyperthyroidism, hypertension, heart disease, diabetes, severe asthma or hypoxemia. Pregnant woman, woman suspected of being pregnant, or lactating woman. Subject who is contraindicated for the use of MRI. Subjects taking caffeine 2 days before or alcohol the day before the trial. Subjects who are judged as not suitable for participation in this study.

Design outcomes

Primary

Measure	Time frame
BOLD signal changes measured by fMRI	—

Countries

Japan

Contacts

Public ContactYumiko Ikeda

Nippon Medical School Department of Pharmacology

y-ikeda@nms.ac.jp03-3822-2131

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026