Type 2 diabetes mellitus
Conditions
Interventions
Subjects: Healthy normal weight subject Acute meal ingestion and exercise load Meal ingestion: 600 kcal of total energy intakes, P:F:C ratio is 15:50:35 Exercise load: 20-min moderate-intensity exe
Sponsors
National Institutes of Biomedical Innovation, Health and Nutrition
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy normal weight subject OR normal weight subject with impaired fasting glucose OR normal weight subject with type 2 diabetes melllitus Normal weight: Body mass index 20-25kg/m2 Impaired fasting glucose: fasting glucose concentration 110mg/dL-126mg/dL Type 2 diabetes melllitus is defiend by a criteria according to the guideline by the Japan diabetes society 2)A subject can perform 20-min moderate-intensty exercise
Exclusion criteria
Exclusion criteria: 1) Excessive body weight fluctuation (5%) during 3 months before an expriment 2) A subject shall not have present history of the disease or anamnesis as follows: Cerebrovascular disorder, heart disease, High blood pressure (grade3) 3) A subject shall not take medicine effecting to energy metabolism or water metabolism, including fibrate-based medicines, bata blocker, diuretic, insulin, GLP-1 analogue, or SGLT2 inhibitors 4) A subject shall not present have history of the disease effecting to energy metabolism or water metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of respiratory quotient during meal ingestion and exercise load | — |
Secondary
| Measure | Time frame |
|---|---|
| Total energy expenditure, daily physical activity, body composition, nutritional status | — |
Countries
Japan
Contacts
Public ContactKazuko Ishikawa-Takata
National Institute of Biomedical Innovation, Health and Nutrition Department of Nutritional Science
Outcome results
None listed