The study to elucidate the mechanism of pathogenesis of atrial fibrillation targeting mitochondria in atrial myocardium

The study to elucidate the mechanism of pathogenesis of atrial fibrillation targeting mitochondria in atrial myocardium - AFMITO Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000024724

Enrollment

Registered

2016-11-08

Start date

2016-11-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with cardiovascular disease who will undergo incision of right atrium in open-heart surgery

Exclusion criteria

Exclusion criteria: 1. Patients who cannot give written informed consent 2. Patients who are considered inappropriate for the study by the principal investigator

Design outcomes

Primary

Measure	Time frame
Mitochondrial oxidative phosphorylation capacity and mitochondrial reactive oxygen species (ROS) release in atrial myocardium	—

Secondary

Measure	Time frame
1.Systemic oxidative stress 2.Systemic inflammation 3.Intramyocellular lipid in atrial myocardium 4.Mitochondrial density in atrial myocardium 5.Gene expression and protein content in atrial myocardium	—

Countries

Japan

Contacts

Public ContactTakashi Yokota

Faculty of Medicine and Graduate School of Medicine, Hokkaido University Department of Cardiovascular Medicine

t-yokota@med.hokudai.ac.jp011-706-6973

Outcome results