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Study to examine the efficacy of modified treat and extend regimen of aflibercept to branch retinal vein occlusion with cystoid macular edema

Study to examine the efficacy of modified treat and extend regimen of aflibercept to branch retinal vein occlusion with cystoid macular edema - Modified treat and extend regimen of aflibercept to branch retinal vein occlusion with cystoid macular edema

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000024587
Enrollment
50
Registered
2016-10-27
Start date
2016-10-27
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

branch retinal vein occlusion

Interventions

Two years of modified treat and extend (1 month) of Aflibercept 2 mg

Sponsors

Jichi Medical University
Lead Sponsor
Aoki Eye Clinic, Okubo Eye Clinic, Saito Eye Clinic, Takahashi Eye Clinic, JCHO Tokyo Shinjuku Medical Center
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patient of branch retinal vein occlusion with cystoid macular edema Onset within 1 year Hope of treatment Willingness to provide written informed consent

Exclusion criteria

Exclusion criteria: Target eye: Prior treatment with anti-VEGF drug and steroid drug Prior treatment with intraocular surgery (<3 months) Another diseases to decrease visual acuity Prior treatment with vitrectomy Fellow eye is already enrolled in the study (If already both eyes onset, the eye which has wider occlusion area is enrolled.) Prior history of brain cardiovascular evebts Patient who the doctor in charge judges are ineligible for the study

Design outcomes

Primary

MeasureTime frame
Visual acuity and central macular thickness at month 12 after initial injection of aflibercept—

Secondary

MeasureTime frame
Visual acuity and central macular thickness at month 24 after initial injection of aflibercept—

Countries

Japan

Contacts

Public ContactHidenori Takahashi

Jichi Medical University Department of Ophthalmology

takahah-tky@umin.ac.jp0285-58-7382

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026