Longitudinal assessment of accumulation of tau-imaging PET tracer [18F]THK-5351

Longitudinal assessment of accumulation of tau-imaging PET tracer [18F]THK-5351 - Longitudinal assessment of tau PET tracer [18F]THK-5351

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000024541

Enrollment

100

Registered

2016-10-25

Start date

2016-10-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer&#39

Interventions

[18F]THK-5351 and [11C]PiB PET studies will be performed in the patients and healthy volunteers. PET images of the brain will be acquired from 40 to 60 min after intravenous administration of 185 mB

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: probable AD (NINCDS-ADRDA Working Group) Mild Cognitive Impairment (petersen's criteria) Frontotemporal Lobar Degeneration (Neary's criteria) Progressive Supranuclear Palsy (NINDS-SPSP International Workshop) Dementia with Lewy Body (McKeith's criteria) Healthy normal subjects without cognitive impairment

Exclusion criteria

Exclusion criteria: Subjects with neuropsychiatric diseases other than inclusion ariteria, subjects with severe cardiac abnormalities, and subjects with pacemaker or metal device in the body.

Design outcomes

Primary

Measure	Time frame
The annual change in the [18F]THK-5351 retention in the brain.	—

Countries

Japan

Contacts

Public ContactAiko Ishiki

Tohoku University Hospital Department of Geriatric Medicine and Neuroimaging

aiko.ishiki.e1@tohoku.ac.jp022-717-7182

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026