gastrointestinal cancer
Conditions
Interventions
Intervention Group:intervention with physical training and amino acids replenishment
Control group:without intervention
Sponsors
Geriatric and General Medicine, Gastroenterological surgery, Osaka University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) the ambulatory patients aged 70 years or older in Osaka University Hospital expecting to undergo digestive operations for gastrointestinal cancers (e.g. stomach/duodenum, esophagus, colorectal, hepatic, gallbladder, bile duct, and pancreas) within stage 3 2) the subjects diagnosed as physical frailty (decline of grip strength and/or gait speed)
Exclusion criteria
Exclusion criteria: 1) the subjects with effort angina, chronic heart failure and tachyarrhythmia 2) the subjects with chronic respiratory failure 3) the subjects with active multiple cancers 4) the subjects who undergo preoperative chemotherapy 5) the subjects not able to walk by themselves 6) the subjects with chronic kidney disease 7) the subjects with severe hepatic dysfunction 8) the subjects with cognitive impairment 9) the subjects participating other clinical investigations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative complications | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) prognosis 1 year after surgery 2) changes of values of comprehensive geriatric assessment (CGA) 3) changes of body composition 4) changes of physical functions 5) changes of several biochemical tests 6) changes of serum concentrations of myokines and vitamin D | — |
Countries
Japan
Contacts
Public ContactHiroshi Akasaka
Osaka University Graduate School of Medicine Osaka University Graduate School of Medicine
Outcome results
None listed