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Comparison of the effect of continuous intravenous infusion and two bolus injections of remifentanil on haemodynamic responses during anaesthesia induction: a prospective open-label randomised trial

Comparison of the effect of continuous intravenous infusion and two bolus injections of remifentanil on haemodynamic responses during anaesthesia induction: a prospective open-label randomised trial - Comparison of the effect of continuous intravenous infusion and bolus injections of remifentanil on haemodynamic responses during anaesthesia induction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000024495
Enrollment
60
Registered
2016-10-20
Start date
2013-10-18
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of anaesthesia

Interventions

remifentanil administration type: the continuous intravenous (IV) infusion group (Group C) remifentanil administration type: the IV bolus group (Group B)

Sponsors

University of Miyazaki
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists physical status (ASA) I-II patients scheduled for elective surgery under general anaesthesia were prospectively enrolled.

Exclusion criteria

Exclusion criteria: Exclusion criteria included patients younger than 20 years of age and with the presence of cardiovascular or cerebrovascular disease, renal failure, or a predicted difficult airway. If tracheal intubation was not performed within 1 minute, this patient was excluded.

Design outcomes

Primary

MeasureTime frame
heart rate and non-invasive blood pressure immediately before tracheal intubation

Secondary

MeasureTime frame
1) heart rate and blood pressure immediately after tracheal intubation 2) heart rate and blood pressure during anaesthesia induction 3) adverse events (HR or SBP decreased to less than 50 bpm or 70 mmHg) 4) use of ephedrine: If HR or SBP decreased to less than 50 bpm or 70 mmHg respectively, IV of 4 mg ephedrine was deemed necessary

Countries

Japan

Contacts

Public ContactToyoaki Maruta

Miyazaki Medical College, University of Miyazaki Departments of Anesthesiology

mmctm2@yahoo.co.jp0985-85-1742

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026