Postgastrectomy Syndrome
Conditions
Interventions
Orally intake acotiamide(100mg) three times a day for 8 weeks starting from 4-7 days post operation.
Sponsors
Nagasaki University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age: Age over 20 years old and below 85 years old at the time of consent 2.Sex: Male and Female 3.In-patient/Out-patient: Either 4.Patients who have undergone gastrectomy and gasric-reconstruction and have started food intake within 3 to 7 days post operation. 5.Patients who consent and sign with complete understanding of the study after adequate explanation as to the particulars of the study, or patients whose guardian consents to their participation in the study.
Exclusion criteria
Exclusion criteria: 1.Cases where gastrectomy was not radical operation (Peritoneal dissemination etc.) 2.Cases with enterostomy 3.Cases with total gastrectomy 4.Patients with medication sensitivity 5.Patients during pregnancy and lactation. 6.Patients who test responsibility (sharing) doctor has determined to be inappropriate as a subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluating symptom diaries utilizing Roma III standards categories (On weeks 1,2,3,4,8) | — |
Secondary
| Measure | Time frame |
|---|---|
| Achieving over 70% of the pre-operational food intake (On weeks 2,4,8). Intra-abdominal fat evaluation and evaluation for atrophy rate of psoas major by CT-scan on the 8 week post surgery. Nutritional index evaluation (prealbumin,retinol-binding protein,albumin,GLP-1), SF-NDI scale,F-scale (On weeks 0,4,8). | — |
Countries
Japan
Contacts
Public ContactShinichiro Kobayashi
Nagasaki University Graduate School of Biomedical Sciences Surgery
Outcome results
None listed