Diabetes
Conditions
Interventions
<
Study1>
Two tests are carried out in a crossover
a simple insulin tolerance test by subcutaneous injection of 0.1 units / kg body weight of insulin and a short insulin tolerance test by intravenous injection of 0.1 units / kg body weight of insulin.
Study2>
A simple insulin tolerance test are carried out in two consecutive days. Each test is completed in the morning.
Sponsors
Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Selection criteria (inpatient) 1. Patient age 20 years of age or older at the time of obtaining informed consent 2. Ppatient with early morning fasting blood glucose greater than or equal to 140 mg/dl at the next day of hosiptalization 3. After receiving a sufficient explanation on participation in this study, on a thorough understanding, patient document consent of the free will of the person has been obtained Selection criteria (volunteer) 1. Age is 30 years of age or older at the time of obtaining informed consent, and BMI 18.5kg/m2 or more persons 2. Person in the past have not been noted diseases which present with diabetes or hypoglycemia 3. After receiving a sufficient explanation on participation in this study, on a thorough understanding, document consent of the free will of the person has been obtained
Exclusion criteria
Exclusion criteria: Exclusion criteria (inpatient) Who 1. state of diabetic retinopathy is not stable 2. diabetic nephropathy stage 4 or more persons Who 3. have merged the untreated ischemic heart disease 4. epilepsy patients 5. for the components of the drug to be used in the present study, a person with a history of hypersensitivity 6. pregnant women, there might have been lactation or pregnancy who 7. other, who principal investigator or research division deems unsuitable as research subjects Exclusion criteria (volunteer) Who 1. in the past has been pointed out the diseases which present with low blood glucose (less than glucose 60 mg/dl) 2. for the components of the drug to be used in the present study, a person with a history of hypersensitivity 3. pregnant women, there might have been lactation or pregnancy who 4. Less than 30 years of age, and BMI 18.5kg/m2 less than those who Who 5. have merged the untreated ischemic heart disease 6. epilepsy patients 7. other, who principal investigator or research division deems unsuitable as research subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation of K index of ITT(Kitt) that is a loss rate of blood sugar of up to 15 minutes -90 minutes of simple insulin tolerance test and Kitt of short insulin tolerance test. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The maximum insulin usage it took to get a good blood sugar control 2.Adverse event 3.Insulin resistance index (HOMA-IR, Kitt) associated with other clinical indicators, such as the blood in the amino acid values, body composition analysis results analysis | — |
Countries
Japan
Contacts
Public ContactTaku Watanabe
Hokkaido University Hospital First Department of Medicine
Outcome results
None listed