Changes of blood volume and physiological parameters after infusion of HES or crystalloid: a randomized-controlled study

Changes of blood volume and physiological parameters after infusion of HES or crystalloid: a randomized-controlled study - Changes of blood volume after infusion of HES

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000024314

Enrollment

100

Registered

2016-10-06

Start date

2016-12-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative patients

Interventions

Intravenous administration of 500 ml of 6% 130 HES in 20 minutes Intravenous administration of 500 ml of 6% 70 HES in 20 minutes Intravenous administration of 500 ml of bicarbonate Ringer&#39

s solution in 20 minutes

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with 1-2 of ASA physical status in elective surgery.

Exclusion criteria

Exclusion criteria: Patients with, hemorrhage, dehydration, body weight (BW) < 35 kg or > 95 kg, cardiovascular disease, pulmonary disease, renal disease, diabetes mellitus, and/or mean arterial blood pressure < 40 mmHg at the baseline measurement.

Design outcomes

Primary

Measure	Time frame
Increases of blood volume and the blood pressure at 10 minutes after the completion of administration of 500 mL of 130 HES, 70HES or bicarbonate Ringer's solution.	—

Secondary

Measure	Time frame
Changes of heart rate, peripheral perfusion index and oxygenation at 10 minutes after the acompletion of administration of 500 mL of 130 HES, 70HES or bicarbonate Ringer's solution.	—

Countries

Japan

Contacts

Public ContactHiroaki Toyama

Tohoku University Hospital Department of Anesthesiology

h-toyama@umin.ac.jp022-717-7321

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026