Gastroesophageal reflux disease
Conditions
Interventions
Administration 20mg of Vonoprazanone for one year
Sponsors
Department of Gastroenterology Nagasaki University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 20 years old, and less than 90 years old. 2. Both of male and female 3. It doesn't no matter with hospitalization or outpatient. 4. Diagnosed accompanied with reflux disease of the newcomer patient, and uncontrolled patient by existing proton pump inhibitor. 5. The patient who have understanding of this study, and obtained written consent by own will.
Exclusion criteria
Exclusion criteria: 1. Liver and kidney dysfunction 2. Allergy to many kind of drugs. 3. Pregnant or who have a possibility to pregnancy, and under nursing patient. 4. Participation to other study in 4 months. 5. The study patient who decided to inadequacy by person in charge. 6. Administration of atazanavir sulfate and rilpivirin hydrochloryde. 7. Severe allergy or complication history of vonoprazan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of IL-8 from tissue of esophageal mucosa taken by biopsy | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms use of F-scale, pH-monitoring, Grade of reflux disease according to Los-Angeles classification, Esophageal manometry, Background, Safety | — |
Countries
Japan
Contacts
Public ContactMaiko Tabuchi
Nagasaki University Hospital Department of Gastroenterology
Outcome results
None listed