schizophrenia
Conditions
Interventions
gluten sensitive patients with schizophrenia have gluten free diet for two weeks. Patients whose symptoms are improved (PANSS score decrease twenty percents or CGI-I score above three at two weeks) c
Sponsors
hyogo medical college department of psychiatry
Mihara hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patient who met the criteria of schizophrenia in the DSM-5 patient who can understand the purpose of this study and be approved to participate by doctor patient who can provide written informed consent
Exclusion criteria
Exclusion criteria: patient with remarkable excitement, violent action, self-injurious behavior patient with social behavior patinet who can't provide written informed consent patient who have substance abuse or dependent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of gluten sensitivity is determined by the titer of tissue transglutaminase IgA antibody, the deamidated gliadin peptide IgA antibody, gliadin IgA antibody, gliadin IgGa nti body. The effectiveness of gluten free diet is assessed by PANSS before and two weeks later of taking gluten free diet. Improved patients is assessed at four and eight weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| The comparison between gluten sensitivity group and gluten negative group is performed by PANSS, GAF, SOFAS, QOL-26. The effectiveness of gluten free diet is assessed by CGI-I | — |
Countries
Japan
Contacts
Public Contactyamada hisashi
hyogo medical college department of psychiatry
Outcome results
None listed