The effects on gut microbiome by taking protom pump inhibitor in the patients with gastroesophageal reflux disease

The effects on gut microbiome by taking protom pump inhibitor in the patients with gastroesophageal reflux disease - proton pmp inhibitor and gut microbiome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000024048

Enrollment

Registered

2016-09-15

Start date

2016-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease

Interventions

vonoprazan 20mg once per day for 28 days and 10mg for 28days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: mild gastroesophageal reflux disease (The Los Angels Classification grade A or B)

Exclusion criteria

Exclusion criteria: Patients already taking proton pump inhibitor or antiacids

Design outcomes

Primary

Measure	Time frame
Microbiota profile at 7 days, 28 days and 56 days after starting PPI use	—

Countries

Japan

Contacts

Public ContactAkiko Shiotani

Kawasaki Medical School Gastroenterology

shiotani@med.kawasaki-m.ac.jp086-462-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026