Development of personalized medicine for depressed patients by elucidating the pathogeneses of depression considering involvement of nutrition, lifestyle and inflammation

Development of personalized medicine for depressed patients by elucidating the pathogeneses of depression considering involvement of nutrition, lifestyle and inflammation - Development of personalized medicine for depression

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000024046

Enrollment

720

Registered

2016-09-14

Start date

2016-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Postpartum depression

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: The subjects consists of: 1. Women who have enrolled to the third generation cohort of Tohoku Medical Megabank Organization (approved by the Ethics Committee of Tohoku University Graduate School of Medicine: 2016-4-013, 2014-4-015), and who experienced delivery before April of 2016, and who have become pregnant between April, 2017 and April, 2021. 2. Women who experienced postpartum depression after the previous delivery are prioritized. 3. People who are 20 years of age or more. 4. People who provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients affected by infectious diseases, malignant tumor, severe diabetes, or other severe systemic diseases. 2. Patients who are considered to be inappropriate to participate to this study, by a physician who is in charge of this project or who is involved in the project.

Design outcomes

Primary

Measure	Time frame
[Postpartum depression assessments] Edinburgh Postnatal Depression Scale: EPDS [Assessment of diagnosis and mental state] Semi-structured interview for evaluating mental state [Plasma] 1. Concentrations of protein, lipid, metabolite, etc. 2. Concentrations of inflammatory substances (cytokine, chemokine, complement components, High-sensitive C-reactive protein etc.) 3. Concentrations of hormones (Estradiol, progesterone, testosterone, cortisol, etc.) [Fecal specimens] Intestinal flora (bifidobacteria, lactic acid bacteria, etc.) [Daily life] 1. Physical activities and movement in daily life 2. Daylight hours 3. Sleeping pattern 4. Heart rate	—

Measure

Time frame

[Postpartum depression assessments] Edinburgh Postnatal Depression Scale: EPDS [Assessment of diagnosis and mental state] Semi-structured interview for evaluating mental state [Plasma] 1. Concentrations of protein, lipid, metabolite, etc. 2. Concentrations of inflammatory substances (cytokine, chemokine, complement components, High-sensitive C-reactive protein etc.) 3. Concentrations of hormones (Estradiol, progesterone, testosterone, cortisol, etc.) [Fecal specimens] Intestinal flora (bifidobacteria, lactic acid bacteria, etc.) [Daily life] 1. Physical activities and movement in daily life 2. Daylight hours 3. Sleeping pattern 4. Heart rate

—

Countries

Japan

Contacts

Public ContactHiroaki Tomita

Tohoku University Graduate school of Medicine Department of Psychiatry

jimu_dpsy@irides-dpsy.med.tohoku.ac.jp81-22-717-7897

Outcome results