Head and neck cancer.
Conditions
Interventions
L-glutamine group: L-glutamine(1-3 pack per day) from 4days before to end of CRT.
Control group: Placebo(1-3 pack per day) from 4days before to end of CRT.
Sponsors
Shiga University of Medical Science Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged >= 20 2) Patients with head and neck cancer. 3) Patients who receive chemoradiotherapy. 4) Recovered from previous chemotherapy and radiotherapy toxicities. 5) Patients who obtained the consent.
Exclusion criteria
Exclusion criteria: 1)Unable intake glutamine formulations per oral or per enteral tube. 2)major impairment of liver 3)major impairment of kidney 4)allergic to L-glutamine 5)pregnant,lactating 6)presence of other cancer under treatment. 7)severe psychosis or psychiatric symptoms 8)paticipation judged by physician to be inadvisable 9)paticipation not taking opioids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CTCAE score for inflammation of oral pharyngeal mucosa. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Physical measurement Body weight, Lean body weight, body fat mass, Grip strength 2)Digestive symptom oral mucositis, taste disturbance, diarrhea, appetite 3)score of Quality of life(QOL) EORT-QLQ-C30 4)Blood test Alb,TP,PA,RBP,serum diamine oxidase activity,IL-6,active ghrelin 5)Amount of total Energy by oral feeding, enteral feeding, parenteral nutrition 6)Duration and dosage of opioid. 7)Rate of CRT completion. | — |
Countries
Japan
Contacts
Public ContactMai Inoue
Shiga University of Medical Science Hospital Clinical nutrition
Outcome results
None listed