Oral cancer
Conditions
Interventions
Kefir intake group(4 to 12 weeks)
Kefir long-term intake group (5 years)
Non-intake group
Sponsors
Hiroshima University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who have been confirmed diagnosed with histologically oral cancer. Untreated case. Patients with measurable lesions that meet the Response Evaluation Criteria in Solid Tumors version1.1. Age at the time of consent acquisition year is 20 years of age or older, less than 80 years old. Performance Status of patient is 0, 1, 2. Major organs, bone marrow, heart, and kidney, function is sufficiently held, that meet the criteria of the following clinical examination within two weeks prior to the registration. 1. leukocyte number is over 4,000 / mm3 and under 12,000 / mm3. 2. platelet count over 100,000 / mm3 3. AST is less than 3 times the normal value facility. 4. total bilirubin is under 1.5mg / dl 5. eGFR is over 60 mL / min / 1.73 m2. 6. On electrocardiogram, no abnormality was observed in need of treatment. Patients written consent has been obtained from person.
Exclusion criteria
Exclusion criteria: Patients with active double cancer. Patients with serious complications, intestinal paralysis, intestinal obstruction, interstitial pneumonia, lung fibrosis, uncontrollable diabetes, heart failure, kidney failure, liver failure. Patients with a hypersensitivity of iodinated contrast agent,milk and dairy products. Patients with severe mental disorders Patients and lactating women that might be pregnant or are pregnant Others, doctor has determined to be inappropriate as a subject of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of the oral flora and intestinal flora Changes in the immune markers such as cell-mediated immunity Response Evaluation Criteria in Solid Tumors Overall survival time, Progression-free survival | — |
Countries
Japan
Contacts
Public ContactRyouji Tani
Hiroshima University Department of Oral Oncology, Graduate School of Biomedical and Health Sciences
Outcome results
None listed