Eczema Food Allergy Asthma Allergic rhinitis
Conditions
Interventions
None listed
Sponsors
Division of General Allergy, Allergy Center, National Center for Child Health and Development
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Infants whose guardians consent to this study during mid-pregnancy and who satisfy both of the following criteria: (1) born at the National Center for Child Health and Development (2) with a family history of atopic dermatitis (at least any one of parents or siblings)
Exclusion criteria
Exclusion criteria: Non-Japanese-speaking caregivers, stillbirths, any other urgent medical attention necessary
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence at 6, 12, 18 months, and 2, 3, 4, 5, 6 years of age and cumulative incidence of each disease at 6 years of age: atopic dermatitis, food allergy (egg, milk), asthma, allergic rhino-conjunctivitis [Time frame: 6 years] [Designated as safety issue: No] | — |
Secondary
| Measure | Time frame |
|---|---|
| Food allergy (wheat, peanut, and others) Asthma severity Total IgE, allergen specific IgEs, TARC/CCL17 Allergen specific IgG4s, affinity of OVA-/OVM-specific IgE Microbiome profiles (skin, gut) EASI (Eczema Area and Severity Index) POEM (Patient Oriented Eczema Measure) | — |
Countries
Japan
Contacts
Public ContactTatsuki Fukuie
National Center for Child Health and Development Division of General Allergy, Allergy Center
Outcome results
None listed