Physiological halitosis
Conditions
Interventions
High-dose extract-containing Chewing gum
Middle-dose extract-containing Chewing gum
Low-dose extract-containing Chewing gum
Control Chewing gum
Sponsors
Lotte Co., Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A. Normally eating three times daily. B. In the screening test, 1.5 ng or more than 1.5 ng of hydrogen sulfide in 10 mL mouth air by gas chromatography. C. No dental treatment now and at least 20 natural teeth. D. Without the habit to brush the tongue during toothbrushing (It was allowed who quitted the tongue brushing during the test period) E. Received the sufficient explanation about the purpose and the content of the study, had the consent ability, volunteered to voluntarily participate in to fully understand, and agreed to the study participation in writing
Exclusion criteria
Exclusion criteria: 1. Smokers 2. Suffering from diabetes mellitus, Chronic nephritis, stomach disorders, lung diseases, malignant tumors, hepatitis, taking medicines. 3. Utilizing mouthwash or anti-malodor products daily. 4. Currently participating or trying to participate in the studies of other medicines or foods. 5. At the screening test, being diagnosed with periodontitis or dental caries. 6. Wearing removable denture. 7. Taking antibiotics / antimicrobial within one month before the screening test. 8. With food allergies, lactose intolerance or feeling of unwellness by the dairy products. 9. Pregnant or with the intention of pregnancy or while breast-feeding during the test. 10. Judged to be inappropriate to the test by the chief researcher because of the other reasons than mentioned above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The concentration of Volatile Sulfur Compounds (hydrogen sulfide and methyl mercaptan) in the oral air | — |
Countries
Japan
Contacts
Public ContactKeishirou Yoshida
LOTTE CO., LTD. Central Laboratory, Food Function Development Section
Outcome results
None listed