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Correlation between the change of the ocular surface and the corneal sensory nerve disorder in patients receiving glaucoma therapy drugs.

Correlation between the change of the ocular surface and the corneal sensory nerve disorder in patients receiving glaucoma therapy drugs. - Corneal sensory neuropathy in patients receiving glaucoma therapy drugs.

Status
Unknown
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000023722
Enrollment
100
Registered
2016-09-01
Start date
2016-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma

Interventions

None listed

Sponsors

Department of Ophthalmology, Ehime University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)Primary open angle glaucoma or ocular hypertension. 2)Patients have been treated with prostaglandine analogs monotherapy.

Exclusion criteria

Exclusion criteria: 1) Any active ocular disease. 2) Subjects unable to tolerate HRTII-RCM. 3) Previous ocular surgery orlaser treatment 4)Patients whom doctor judged to be ineligible for this study.

Design outcomes

Primary

MeasureTime frame
To evaluate differences in long nerve fiber density (LNFD) of corneal parameters between glaucoma patients and controls using in vivo confocal microscopy. Glaucoma patients are sub-grouped according to the period of usage of eye drops.—

Secondary

MeasureTime frame
corneal sensitivity, epithelial staining, tear volume, etc.—

Countries

Japan

Contacts

Public ContactXiaodong Zheng

Ehime University Ophthalmology

zheng.xiaodong401@gmail.com089-960-5361

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026