Repetitive Transcranial Magnetic Stimulationfor 2010 criteria diagnosed Fibromyalgia with a comorbidity of depression: Evidence from a pilot Randomized Sham-Controlled Study

Repetitive Transcranial Magnetic Stimulationfor 2010 criteria diagnosed Fibromyalgia with a comorbidity of depression: Evidence from a pilot Randomized Sham-Controlled Study - the analgesic effect of rTMS in patients with modified 2010 ACR and comorbided with major depressive disorder

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023721

Enrollment

Registered

2016-08-22

Start date

2013-10-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A treatment option for Medication-resistant fibromyalgia

Interventions

Left DLPFC 10Hz rTMS group (1 session/day, 5 days/week,2weeks)

100% motor threshold,1600 pulses once Sham group(1 session/day, 5 days/week,2weeks) using a sham coil.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: adult patients with a modified ACR 2010 diagnosis of fibromyalgia and major depressive disorder

Exclusion criteria

Exclusion criteria: Patients were excluded if they had a lifetime psychiatric history of psychotic disorders, bipolar I or II disorder, substance abuse or dependence, personality disorders (based on DSM-IV criteria) or a lifetime medical history of major systemic illness, neurological disorders (e.g. stroke, post-brain surgery, epilepsy, traumatic brain injury), or cardiac pacemakers, brain implants or neurostimulators; or if they were pregnant.

Design outcomes

Primary

Measure	Time frame
the changing of VAS-pain (week-2 vs. baseline) in response to the 2-week prefrontalrTMS	—

Secondary

Measure	Time frame
FDG-PET; CANTAB for working memory, go/no-goand MSCEIT; serum IL-2, IL-6, TNF-alpha, insulin, CRP; Young mania Rating scale; Clinical Global Index; Hamilton Depression Rating Scales-17 item; Life stress scale; Pittsburgh Sleep Quality Index;12-Item Short Form Health Survey; short-form McGill Pain Questionnaire; Patient Health Questionnaire	—

Countries

Asia(except Japan)

Contacts

Public ContactCheng-Ta Li

Taipei Veterans General Hospital, Taiwan Psychiatry

on5083@msn.com+88628757027

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026