Skip to content

Elucidation of human brain network and functional plasticity in patients with epilepsy: a cortico-cortical evoked potential study using an intracranial electrode

Elucidation of human brain network and functional plasticity in patients with epilepsy: a cortico-cortical evoked potential study using an intracranial electrode - Elucidation of human brain network and functional plasticity in patients with epilepsy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000023682
Enrollment
100
Registered
2016-08-19
Start date
2016-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy, Brain tumor, Cerebral vascular malformation

Interventions

Single-pulse or paired-pulse electrical stimuli will be applied bipolarly to a pair of adjacent intracranial electrodes at the stimulus intensity within safe limits. We aim to elucidate the static and

Sponsors

Kyoto University
Lead Sponsor
Kyoto University Ehime University Ritsumeikan University RIKEN Hokkaido University Kyoto Sangyo University Kyushu Institute of Technology Fukuoka Institute of Technology INS Institut de Neurosciences des Systemes, UMR INSERM 1106, Aix Marseille Universite Department of Neurology, Johns Hopkins University School of Medicine Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King&#39
Collaborator
s College London Epilepsy Center, Cleveland Clinic
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: We will recruit the patients with medically intractable partial epilepsy and those with neurosurgical diseases.

Exclusion criteria

Exclusion criteria: A patient whose consent can not be obtained.

Design outcomes

Primary

MeasureTime frame
Cortico-cortical evoked potentials (CCEPs), subcortico-cortical evoked potentials (SCEPs), and stimulus-induced wide-band brain activities recorded from intracranial electrodes elicited by single pulse electrical stimuli to the cerebral cortex and white matter.

Secondary

MeasureTime frame
Activities recorded from microelectrodes in case of simultaneous intracranial macroelectrodes and microelectrode recording.

Countries

Japan,North America,Europe

Contacts

Public ContactKatsuya Kobayashi

Kyoto University Graduate School of Medicine Department of Neurology

31258a@kuhp.kyoto-u.ac.jp075-751-3772

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026