Unipolar mood disorders, Anxiety disorders
Conditions
Interventions
Group cognitive behavioral therapy (Unified Protocol)
Sponsors
National Center of Neurology and Psychiatry
Keio University School of Medicine Nishimura clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects with current DSM-IV Panic disorder with/without Agoraphobia, Agoraphobia without history of Panic Disorder, Specific Phobia, Social Phobia (Social Anxiety Disorder), Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorder, Generalized Anxiety Disorder, Major Depressive Disorder, Dysthymic disorder 2. The Clinical Global Impressions Scale-Severity of illness >= 4 3. Age 20 years or older, and 65 years or younger at screening 4. Subjects who give full consent in the participation of the study
Exclusion criteria
Exclusion criteria: 1. No alcohol or substance use disorder in a year prior to the baseline 2. No manic episode or psychotic disorders at baseline 3. No serious suicidal ideation at baseline (GRID-HAMD Item 3 symptom intensity is less than moderate) 4. Evidence of unable to participate half or more of the intervention phase 5. No structured psychotherapy (except supportive therapy) during the intervention 6. No major cognitive deficits or No life-threatening, severe or unstable physical disorders at baseline 7. Other relevant reason decided by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.The Clinical Global Impressions Scale-Severity(CGI-S) 2.Objective severity of depressive symptoms(GRID-HAMD) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The Clinical Global Impressions Scale- Improvement(CGI-I) 2. Subjective severity of Anxiety and impairment(OASIS) 3. Subjective severity of Depression and impairment(ODSIS) 4. Quality of life(EQ-5D-5L) 5. Function(SDISS/GAF) 6. Emotion Regulation(ERSQ) 7. Neuroticism(EPQR-S) 8. Subjective symptoms for primary diagnosis 9. Drop Out rate 10. Adverse Event | — |
Countries
Japan
Contacts
Public ContactNoriko Kato
National Center of Neurology and Psychiatry National Center for Cognitive Behavior Therapy and Research
Outcome results
None listed