Respiratory disease, which is an indication of flexible bronchoscopy
Conditions
Interventions
None listed
Sponsors
Department of Respiratory Medicine Nagoya University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing bronchoscopy in Nagoya University Hospital 2. Age is 20 years or older 3. Written consent for participation in the study from the patient himself has been obtained 4. Patient with mental state that can enforce the investigation by questionaire 5. Laboratory test values within the preceding 14 days registration meets the following criteria: a) AST / ALT < 3 times the facility references value upper limit b) 1.5 times the total bilirubin value < facility reference value upper limit c) following serum creatinine 1.5mg / dl d) SpO2 > 90% in the room air
Exclusion criteria
Exclusion criteria: 1. Patients with SpO2 <90% in the room air 2. There is a history of severe drug hypersensitivity, including hypersensitivity to midazolam 3. Patients with a neuromuscular disease 4. Patients with acute angle-closure glaucoma 5. Patients with myocardial infarction within-onset 6 weeks 6. Patients with other serious complications 7. Patients whom the attending physician has determined to be inappropriate as a subject of the present study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence rate of hypoxemia during bronchoscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Blood concentrations of midazolam (after the initial dose, after adding administration) 2. MOAA/S scale 3. The bispectral index (BIS) 4. Questionnaire about the sedation 5. Adverse events 6. Correlation between gene polymorphism and efficacy or safety of sedation | — |
Countries
Japan
Contacts
Public ContactShotaro Okachi
Nagoya University Hospital Department of Respiratory Medicine
Outcome results
None listed