A prospective observation study of carbon-ion radiotherapy and concurrent S-1 chemotherapy for locally advanced pancreatic cancer (GUNMA1501)

A prospective observation study of carbon-ion radiotherapy and concurrent S-1 chemotherapy for locally advanced pancreatic cancer (GUNMA1501) - Carbon-ion radiation therapy with S-1 for Locally advanced pancreatic cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023602

Enrollment

Registered

2016-08-12

Start date

2015-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Locally advanced pancreatic cancer

Interventions

Carbon-ion radiation therapy. 55.2Gy(RBE)/12fractions/3weeks S-1 80mg/m2/day 4weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Histlogical diagnosed invasive pancreatic cancer 2) without gastric ulcer 3) T stage is T4 (UICC 7th) 4) without direct invasion to GI tract 5) patient age is between 20 to 80 years old 6) performance status is 0-2 7) No history of surgery or irradiation for pancreatic cancer

Exclusion criteria

Exclusion criteria: 1) direct invasion to GI truct 2) visivle ascites 3) use of metalic billiary stent 4) use of Flucytosine, phenytoin or warfarin 5) active scar or infection within the irradiation area 6) severe co-occurring disorders (diabetes mellitus, heart failure and so on) 7) co-occurring malignancies 8) Chemotherapy history over 3 month 9) History of irradiation to the irradiating area

Design outcomes

Primary

Measure	Time frame
2 year overall survival rate	—

Countries

Japan

Contacts

Public ContactMasahiko Okamoto

Gunma University Gunma University Heavy Ion Medical Center

okamott@gunma-u.ac.jp027-220-8378

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026