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A confirmatory multi-institutional joint research of the amyloid beta deposition in the brain of non-amnestic Alzheimer's disease and mild cognitive impairment patients

A confirmatory multi-institutional joint research of the amyloid beta deposition in the brain of non-amnestic Alzheimer's disease and mild cognitive impairment patients - A clinical research of the cerebral amyloid beta deposition using amyloid-PET imaging in non-amnestic Alzheimer's disease and mild cognitive impairment patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000023528
Enrollment
12
Registered
2016-08-08
Start date
2016-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-amnestic Alzheimer&#39

Interventions

All subjects undergo amyloid PET once within six months from the date of agreement in principle. Additional amyloid PET will be needed in case of unclear result.

Sponsors

Kobe University Graduate School of Medicine
Lead Sponsor
Institute of biomedical research and innovation, Kobe
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Subjects who fulfill the following all criteria. A. Possible non-amnestic Alzheimer's disease (including mild cognitive impairment) patient whose clinical feature is one of the following. 1. language disorder type (logopenic aphasia type) 2. visuospatial disorder type (posterior cortical atrophy type ) 3. executive dysfunction type 4. corticobasal syndrome type B. Able to understand the research content and to sign the letter of informed consent by subject or study partner.

Exclusion criteria

Exclusion criteria: Subject who applies to any of the following criteria will be rejected. 1. Vascular dementia suspected by MRI, Hachinski score or NINDS-AIREN criteria. 2. Treatable dementia caused by metabolic disease, head trauma, normal pressure hydrocephalus (NPH), and so on. 3. Suspected psychiatric disorders, such as schizophrenia or major depression. 4. Cannot keep lying on bed for about 30 minutes. 5. Severe claustrophobia (fear of closed space). 6. MRI exclusions, such as presence of pacemaker or aneurysm clips. 7. Incapable of taking psychological test for any reason. 8. Pregnant woman suspected by medical interview. 9. Other exceptions considered by project leader or collaborators.

Design outcomes

Primary

MeasureTime frame
Outcomes are not applicable because this study is confirmatory research of small sample size and quantitative analysis is difficult.—

Secondary

MeasureTime frame
Outcomes are not applicable because this study is confirmatory research of small sample size and quantitative analysis is difficult.—

Countries

Japan

Contacts

Public ContactKenichi Matsuyama

Kobe University Graduate School of Medicine Department of Psychiatry

matu054909@yahoo.co.jp078-382-6065

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026