A prospective multicenter observational study of surgical palliation examining postoperative quality of life in patients treated for malignant gastric outlet obstruction caused by incurable advanced gastric cancer

A prospective multicenter observational study of surgical palliation examining postoperative quality of life in patients treated for malignant gastric outlet obstruction caused by incurable advanced gastric cancer - gastric outlet obstruction (GOO)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000023494

Enrollment

100

Registered

2016-08-05

Start date

2013-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric Cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) histologically proven primary gastric adenocarcinoma presenting with GOO diagnosed clinically, endoscopically, or radiographically (2) presence of non-curable factors confirmed by both enhanced abdominal computed tomography (CT) and exploratory laparoscopy or laparotomy (3) no oral intake or extremely poor oral intake requiring parenteral nutrition (4) age of 20 years or more (5) surgically fit (6) Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 through 2 (7) adequate organ function within 14 days before enrollment, and (8) written informed consent (IC).

Exclusion criteria

Exclusion criteria: (1) active bleeding or perforation of the gastric tumour demanding an urgent surgery; (2) active coexisting cancer (synchronous coexisting cancer and recurrence of metachronous cancer) showing symptoms; (3) clinically suspected brain metastasis or carcinomatous meningitis; (4) presence of disseminated intravascular coagulation (DIC); and (5) severe mental disorder.

Design outcomes

Primary

Measure	Time frame
Changes in QOL for patients undergoing surgical palliation for GOO caused by incurable primary gastric cancer.	—

Secondary

Measure	Time frame
Postoperative improvement of oral intake, safety of surgical procedures, and postoperative overall survival.	—

Countries

Japan

Contacts

Public ContactKazumasa Fujitan, MDi

Osaka Prefectural General Medical Center Surgery

fujitani@onh.go.jp06-6692-1201

Outcome results