Comparion of the infusion rate of rocuronium necessary for obtain adequate surgical muscle relaxation between before and during hepatectomy with Pringle maneuver.

Comparion of the infusion rate of rocuronium necessary for obtain adequate surgical muscle relaxation between before and during hepatectomy with Pringle maneuver. - Comparion of the infusion rate of rocuronium between before and during hepatectomy with Pringle maneuver.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023479

Enrollment

Registered

2016-08-08

Start date

2016-08-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical patients requiring hepatectomy with Pringle maneuver

Interventions

We adjust a continuous rocuronium infusion rate to keep T1 twitch hight from 3 to 10% with acceleromyography on the adductor pollicis in response to electrical stimulation of the ulnar nerve, also kee

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)ASA physical status 1~3 2)age=>20 3)total venous anesthesia with propofol 4)Operation time=>3hours 5)written informed consent was obtained from the patients before the surgery

Exclusion criteria

Exclusion criteria: excluded if any one of the following criteria applied: 1) probably pregnant 2) abnormal serum electrolytes (Na +, K +, or Cl-) 3) renal dysfunction (serum creatinine greater than 2.0 mg/dl) 4) liver dysfunction (ALT and/or AST beyond twice the normal range) 5) ICG15=>15% 6) Child-Pugh classification=>B 7) emaciation (body mass index (BMI) less than 17), obesity (BMI more than 30) 8) neuromuscular disorders, 9) a history of hypersensitive reaction to Rb, 10) a history of treatment with drugs known to interact with Rb, such as aminoglycoside antibiotics, anticonvulsants, formulation lithium, or magnesium 11) hypothermia during anesthesia 12) systemic allergy 13) inappropriate patients judged by physician-in-charge

Design outcomes

Primary

Measure	Time frame
continuous infusion rate for obtain muscle relaxasion(before, during, and after Pringle maneuver)	—

Secondary

Measure	Time frame
measured blood concentration of rocuronium during stable state of optimalmuscle relaxation	—

Countries

Japan

Contacts

Public ContactAkira Kajiura

Saitama Medical Center, Jichi Medical University Department of Anesthesiology and Critical Care Medicine

kajiura-hki@umin.ac.jp048-647-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026