Randomized control stuy for the effect of dentifrice including mastic and fulvic acid on periodontal symptoms

Randomized control stuy for the effect of dentifrice including mastic and fulvic acid on periodontal symptoms - Effect of dentifrice including mastic and fulvic acid

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023456

Enrollment

Registered

2016-08-03

Start date

2016-08-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodontal disease

Interventions

Dentifrice A:Mastic essential oil(0.01g) Instructed to use dentifrice(1g),1cm for 7 min twice a day(morning, evening) during 12 weeks. Dentifrice B: Mastic essential oil(0.01g)+ Fulvic acid(10g)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Chronic periodontitis patients who did not received scaling at observed site within 6 months and are at first visit or plaque control stage.

Exclusion criteria

Exclusion criteria: A) Systemic diseases which affect to periodontal tissue B) Severe periodontal diseases C) Anteriol teeth lost or applied orthodontic apparatus D) Pregnant or lactating woman E) Antibiotics experience within 3 months

Design outcomes

Primary

Measure	Time frame
clinical parameters such as swelling and redness of gingiva, bleeding, discharge of pus, periodontal pocket depth, moving of teeth, halitosis and whiteness of teeth were evaluated at start of dentifrice usage,4,8 and 12 weeks later	—

Secondary

Measure	Time frame
microbiological test was performed at dentifrice usage, 4, 8 and 12 weeks later	—

Countries

Japan

Contacts

Public ContactAkiho Sato

Tokyo Medical and Dental University the general affairs section

rec.adm@tmd.ac.jp03-5803-5404

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026