Prostate cancer
Conditions
Interventions
Sponsors
Kyoto University Graduate School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Adults younger than 85 years, histologically confirmed adenocarcinoma of the prostate cancer with PSA recurrence (PSA>= 0.2 ng/ml, 2 rising PSA tests with >= at least 2-week interval between each determination ) after radical prostatectomy including patients after salvage radiation therapy to prostatic bed; no prior or present evidence of metastatic disease; ECOG 0~2; no surgery or radiation allowed within 4 weeks before day 1.
Exclusion criteria
Exclusion criteria: Previously treated or currently be receiving hormonal therapy with the intent to treat prostate cancer (surgical castration or other hormonal manipulation, e.g. GnRH agonists or antagonists, anti-androgens or estrogens); Evidence of administration of greenpropolis or other alternative therapies within 3 months before day 1. History of allergy against honey, a coniferous tree, a poplar, Peru balsam, and salicylic acid; History of atopic dermatitis, chronic recurrent eczema, and asthma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSA response rate | — |
Secondary
| Measure | Time frame |
|---|---|
| PSA response duration time to PSA progression PSA slope before and after administration of propolis Changes of serum testosterone level IHC of AKR1C3, AR, and ERG of prostatectomy specimens QOL Proportion of adverse events | — |
Countries
Japan
Contacts
Public ContactTakahiro Inoue
Kyoto University Graduate School of Medicine Urology
Outcome results
None listed