Patients with coronary artery disease requiring percutaneous coronary intervention (PCI), and with LDL-C >
Conditions
Interventions
Intravascular ultrasound (and optical coherence tomography, if possible) will be performed to observe coronary plaque of non-culprit lesions at follow-up coronary angiography 12 months after stent imp
Sponsors
Chiba University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with coronary artery disease requiring percutaneous coronary intervention 2) Patients with LDL-C >= 100 mg/dl even on statin therapy for at least 4 weeks, either with or without familial hypercholesterolemia 3) 20 to 85 years old 4) Signed written informed consent
Exclusion criteria
Exclusion criteria: 1) Difficulty to observe the coronary arteries, including non-culprit lesions, by IVUS at PCI procedure 2) Severe hepatic insufficiency 3) Severe renal insufficiency 4) Severe heart failure (left ventricular ejection fraction <30%, or NYHA class III or IV) 5) intolerance or allergy to statin 6) Pregnant, postpartum within 28 days, or breast-feeding 7) Recognized as inadequate by attending doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in percent atheroma volume (PAV) in non-culprit lesions from baseline to follow-up (12 months after PCI) as measured by intravascular ultrasound (IVUS) | — |
Countries
Japan
Contacts
Public ContactHideki Kitahara
Chiba University Graduate School of Medicine Department of Cardiovascular Medicine
Outcome results
None listed