Odontogenic bacteremia
Conditions
Interventions
Application of dilute sodium hypochlorite super-oxidized water to periodontal tissue (including pocket region) by using dental custom tray twice a day for 90 days after initial preparation.
Initial pr
Sponsors
Tsurumi University School of Dental Medicine, Department of Translational Research
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Those who agreed to participate in the study with written informed consent. 2. Those who have 20 or more functioning teeth. 3. Those who have periodontitis with bleeding on probing (more than two sites) and/or with 4 mm or larger pocket (more than one site).
Exclusion criteria
Exclusion criteria: 1. Those who are unable to travel to the institutions by themselves. 2. Those who need periodontal surgery. 3. Those who need prosthodontic treatment. 4. Those who have untreated cavity. 5. Those who have semi-impacted tooth (one or more). 6. Those who have undergone an antibiotic therapy within 3 months before the start of study. 7. Those who need to be medicated routinely (except for supplements such as vitamins). 8. Those who might (or will) need any other treatment in high-priority than periodontal treatment. 9. Those who are participating in another clinical trial. 10. Those who were or will be judged inappropriate by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in arterial flow mediated dilation between before and after 90 days of intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in periodontal parameters, blood pressure, body composition, level of fatigue, serum levels of ADMA, CRP, IL-6, glucocorticoid and IL-8, salivary levels of amylase and glucocorticoid, and major oral pathogens between before and after 90 days of intervention. | — |
Countries
Japan
Contacts
Public ContactMeu Ariyoshi
Tsurumi University School of Dental Medicine
Outcome results
None listed