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L-menthol and carbon dioxide improve adenoma detection rate during colonoscopy; a randomized trial

L-menthol and carbon dioxide improve adenoma detection rate during colonoscopy; a randomized trial - L-menthol and carbon dioxide improve adenoma detection rate during colonoscopy; a randomized trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000023383
Enrollment
600
Registered
2016-07-28
Start date
2016-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal neoplasmas

Interventions

0.8% l-Menthol with Carbon dioxide 0.8% l-Menthol with Air Water with dimeticon with Carbon dioxide Water with dimeticon with Air

Sponsors

Division of Gastroenterology and Hepatology,Fukuchiyama City Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: The patients undergoing colonoscopy for the investigation of positive results of a fecal occult blood test screening, screening colonoscopy or surveillance colonoscopy after postendoscopic resection of colorectal neoplasmas.

Exclusion criteria

Exclusion criteria: Patients were excluded if they had any of the following: a history of colectomy,symptoms suggesting possible colorectal stenosis or cancer, inflammatory bowel disease, familial polyposis, or known CRC, severe organ failure, noncorrectable coagulopathy, or antithrombotic therapy.

Design outcomes

Primary

MeasureTime frame
The colorectal adenoma detection rate between the L-menthol with carbon dioxide group and the placebo group.

Secondary

MeasureTime frame
The proportion of patients with no peristalsis, the withdrawal time and the pain during colonoscopy between the L-menthol with carbon dioxide group and the placebo group.

Countries

Japan

Contacts

Public ContactKen Inoue

Fukuchiyama City Hospital Gastroenterology and Hepatology

keninoue71@koto.kpu-m.ac.jp+81-773-22-2101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026