Exploratory study to determine S-588410-induced tumor infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients

Exploratory study to determine S-588410-induced tumor infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients - Exploratory study to determine S-588410-induced tumor infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023324

Enrollment

Registered

2016-08-01

Start date

2016-07-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

S-588410 will be injected subcutaneously once weekly, 5 times or more in total.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients who are male or female aged 20 years or more at the time of informed consent. 2)Patients who are willing to supply the tumor tissue 3)Patients with esophagus squamous cell carcinoma or adenocarcinoma histologically 4)HLA-A*24:02-positive patients 5)The patient who can initiate the administration of the test drug more than 30 days before the esophagus resection

Exclusion criteria

Exclusion criteria: 1)The patient who are going to receive or received the following treatment for the primary disease /Antineoplastic drug /Radiotherapy /Thermotherapy /Systemic immunosuppressant /immunotherapy 2)Patients with uncontrolled systemic or active infection.

Design outcomes

Primary

Measure	Time frame
Tumor-infiltrating CD8-positive lymphocytes	—

Secondary

Measure	Time frame
Cytotoxic T cell	—

Countries

Japan

Contacts

Public ContactKyokawa Yoshimasa

Shionogi & Co., Ltd. Corporate Communications Department

shionogiclintrials-admin@shionogi.co.jp06-6209-7885

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026