Frail elderly subjects
Conditions
Interventions
The first group (positive control) receives leucine-, vitamin D-enrich supplement plus MCT (LD + MCT) at dinner. The leucine-, vitamin D-enrich supplement (Amino L40) produced by Ajinomoto Inc. (To
Sponsors
Showa Women's University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Elderly subjects in a nursing care home for the elderly volunteered to participate in a 3-mo dietary supplement intervention program. All residents in this nursing care home need special care by other people for living. They are classified into Japanese nursing care levels with number between 1 and 5 based on assessed care needs.
Exclusion criteria
Exclusion criteria: Exclusion criteria are subjects with treated with parenteral nutrition, or difficulty of swallowing, or type 1 diabetes mellitus, severe heart failure, liver, kidney, blood disease, or FBS > 200 mg/dl, or blood creatinine > 1.5 mg/dl or CRP > 2.0 mg/dl or BMI > 23 to avoid a further increase in body weight, or food allergy to supplements used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Iteration numbers in legs open and close | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle function (locomotive and respiratory) and cognitive function at baseline, during 3-mo intervention and at washout are measured. Mid-upper-arm muscle area (AMA) is estimated by measuring triceps skin fold thickness (TSF) and mid-upper-arm circumference (AC); strength in the upper extremities is measured by a handgrip dynamometry; strength in the lower extremities is estimated by the leg extension power. Muscle function is estimated by gait speed; swallowing ability is estimated by repetitive saliva swallowing test; strength of respiratory muscles is estimated by peak expiratory flow (PEF); ADL is estimated by Functional Independence Measure (FIM). Cognitive function is estimated by Mini-Mental State Examination (MMSE), NM scale, and Neuropsychiatric Inventory Nursing Home Version (NPI-NH). | — |
Countries
Japan
Contacts
Public Contactosamu ezaki
Showa Women's University Institute of Women's Health Science
Outcome results
None listed